Cisplatin nmr

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WebThe paper gives an overview of the basic NMR techniques particularly relevant for studying interaction between platinum compounds and nucleic acid constituents. The latest NMR … WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck …

Cisplatin - The Penicillin of Cancer

WebJan 4, 2011 · Abstract. The influences of solvent effects and dynamic averaging on the 195 Pt NMR shielding and chemical shifts of cisplatin and three cisplatin derivatives in … WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. … polyethylene glycol peg laxatives

Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to

Antitumor agent cisplatin1 and its derivatives,2,3 when used alone or in combination with other chemotherapeutics4,5 can be effective against the advancement of several clinical cases of cancer. However, there are several known factors such as low selectivity, resistance and consequently, high toxicity that are … See more The calculations were carried out using the GAUSSIAN 09 package.34 The methodology used for the prediction of the NMR chemical shifts … See more In this work we used the relativistic NMR-DKH basis sets for the calculation of the 1H, 15N and 195Pt NMR spectra of inclusion complexes formed between cisplatin and … See more In this work we re-optimize the geometries of the molecular models of cDDP@CNTox or complex I (C168H24O15Cl2N2Pt) and cDDP@CNCox or … See more L. A. De Souza thanks the CAPES for a Post-Doctoral scholarship (Proc. No. 88882.306139/2024-01) during the period 2024–2024 at Universidade Federal Fluminense and support provided by Professor J. C. … See more WebMay 26, 2024 · Cisplatin is a well-known chemotherapeutic drug for solid tumors and leukemia with muscle toxicity, and long-term cisplatin medication can induce aberrant … Web195Pt and 15N nuclear magnetic resonance (NMR) was used to study the chemical equilibria of cisplatin in water and plasma ultrafiltrate (PUF). Cisplatin was found to be … polyethylene glycol pills

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WebSep 9, 2024 · Response of Cisplatin Resistant Skov-3 Cells to [Pt ( O,O'-Acac) (γ-Acac) (DMS)] Treatment Revealed by a Metabolomic ¹H-NMR Study Response of Cisplatin Resistant Skov-3 Cells to [Pt ( O,O' -Acac) (γ-Acac) (DMS)] Treatment Revealed by a Metabolomic ¹H-NMR Study 2024 Sep 9;23 (9):2301. doi: 10.3390/molecules23092301. … WebHowever, like cisplatin and transplatin, only the cis isomer has anti-cancer activity, whereas the trans-isomer does not. ... The solution structure of the platinum-DNA adducts has been studied by two-dimensional NMR spectroscopy. Both the cis-platinum adducts and the trans-platinum adducts destabilize the DNA duplex significantly. The melting ... polyethylene glycol powder dosageWebFeb 9, 2001 · Our studies on STEALTH cisplatin show that NMR is a powerful tool in the characterization of drug-lipid interactions, the physical state of the drug inside the … poly ethylene glycol powder oral 70 g

"WebOct 22, 2024 · In NMR analysis, the effect of C. nutans aqueous extract against cisplatin on NRK-52E was quantitatively determined relative to the concentration of the internal reference standard, trimethylsilyl propionic acid (TSP). The concentration of the metabolites in NRK-52E cells extract and culture media of treated and non-treated groups and their ... " - Cisplatin nmr

Cisplatin nmr

Impact of chemotherapy on metabolic reprogramming: …

WebFeb 1, 2012 · Cisplatin, 1, was used as purchased (Sigma-Aldrich, St. Louis, MO). Stock solutions of the platinum compounds in distilled water, 1 and 3, or DPBS (Dulbecco's phosphate buffered saline) buffer, 4, were in the range of 40–650 μM. WebJun 10, 2024 · NMR-based metabolomics is a very effective tool to assess the tumor response to drugs by providing insights for their mode of action. Recently, a novel Pt (II) complex, [Pt (ƞ 1 -C 2 H 4 OMe) (DMSO) (phen)] + (phen = 1,10-phenanthroline), Pt-EtOMeSOphen, was synthesized and studied for its antitumor activity against eight …

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WebFeb 1, 2007 · The paper gives an overview of the basic NMR techniques particularly relevant for studying interaction between platinum … WebThe purity of the complexes and their stability in solution was confirmed by NMR analysis. The Pt(II) ions in all compounds are in a square planar environment. ... D. Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects. Cancers 2011, 3, 1351–1371. [Google Scholar] [Green Version] Cooley ...

WebJan 11, 2024 · Cisplatin [ cis -diamminedichloridoplatinum (II)] is a widely used chemotherapeutic drug in the treatment of various types of cancers, including testicular, bladder, ovarian, breast, head and neck, and small and non-small cell lung cancers. WebMay 1, 2024 · The equilibrium structures of cisplatin and transplatin were optimized, and their 1 H, 15 N, and 195 Pt NMR chemical shifts were evaluated at both non-relativistic and fully relativistic four-component levels. Reliable correlations with experimental data were achieved at the DFT level with taking into account relativistic effects in calculations of …

WebSep 25, 2024 · The confirmation of bioconjugation of cisplatin with B-GNPs was done by UV-Visible spectroscopy, TEM, FTIR, 2D 1 H NMR DOSY and ICP-MS. Further, it was found that almost ~4 cisplatin molecules ... WebApr 9, 1999 · NMR studies of the activation of cisplatin and related complexes, DNA platination, reactions with amino acids, peptides and proteins are discussed in this …

WebIntroduction. Cisplatin (cis-diamminedichloroplatinum(II)) is one of the most widely used first-line chemotherapeutic agents for a broad range of cancers.Cisplatin continues to be in widespread clinical use for various solid tumors such as ovarian, testicular, bladder, head and neck, and non-small cell lung cancers 1,2 but its usefulness is limited due to its high …

WebPt NMR shows that cisplatin is not produced in the reaction medium. Although the Pt(II) products bind to closed circular DNA, their effect on the mobility of Form I DNA is different from that produced by cisplatin. When physiolog-ical carbonate is present in the reduction medium, 13. C NMR shows that Pt(II) carbonato complexes form polyethylene glycol pregnancy categoryWebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. This activity reviews the indications, action, and … polyethylene glycol prep for colonoscopyWebOct 22, 2024 · NMR and LCMS analysis highlighted choline, creatine, phosphocholine, valine, acetic acid, phenylalanine, leucine, glutamic acid, threonine, uridine and proline … shangri-la midtown detroitWebMay 1, 2024 · Geometries and NMR properties of cisplatin and transplatin revisited at the four-component relativistic level. The equilibrium structures of cisplatin and transplatin … shangri la mansfield woodhouseWebOct 3, 2013 · Abstract. In this work, 1 H high resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was used to characterize the … shangri la massage spa - south miamiWebApr 1, 2014 · 1 H and 13 C NMR spectra were recorded on a Bruker AV 400 NMR spectrometer in DMSO-d 6. Fourier transform infrared (FT-IR) spectra were recorded on a Bio-Rad Win-IR instrument using KBr method. ... Moreover, cisplatin crosslinking could largely enhance micellar stability and might effectively prevent premature drug release … shangri la miles to pointsWebIn this paper we illustrate how NMR spectroscopy can provide new insights into the mechanism of action of platinum anticancer drugs, including the detection of intermediates in DNA platination reactions and metabolites in body fluids. ... J.D. Ranford and P.J. Sadler, Hydrolysis products of cisplatin: pK a determinations via [1 H, 15 N] NMR ... shangri la mental health salem oregon